Package org.biojava.bio.dp

Interface StatePath

All Superinterfaces:

Alignment, Changeable, SymbolList

All Known Implementing Classes:

SimpleStatePath

public interface StatePath
extends Alignment

Extends the Alignment interface so that it is explicitly used to represent a state path through an HMM, and the associated emitted sequence and likelihoods.

A state path should have the following structure: STATES -> list of all states used by the machine
SCORES -> list of step-wise scores for each state (transition + emission)
SEQUENCE -> sequence emitted by the machine The sequence emitted by the machine will be some function of the sequences that were aligned to the machine, and the state-path taken. Whenever the state used is a non-emitting state, this emitted sequence is a gap. Whenever it is an emission state, it is the symbol matched by that state. This is modeled by the following nesting:

 SEQUENCE
   -> Gapped view (gap inserted for every position aligned with a dot-state
     -> Sequence emitted by emission states as Alignment
       label_n = input_SymbolList_n
         -> gapped view of SymbolList_n
 

A multi-head HMM (2 or more) emits a single sequence that is an alignment of the input sequences with gaps added. In this case, the emitted sequence should be an Alignment object with labels being the input sequences, and the associated SymbolList objects being gapped views. For the sake of least-suprise, single-head HMMs should emit an alignment of one sequence, where the label is the input sequence, and the associated SymbolList is also the input sequence.

I think that this scheme keeps the emitted alignment as close as possible to a sensible path through the sequence coordinate space, while making this gappable adapts this to the same co-ordinate system as the HMM state-path space.

Author:

Matthew Pocock

Nested Class Summary

Nested classes/interfaces inherited from interface org.biojava.bio.alignment.Alignment

Alignment.SymbolListIterator

Field Summary

Fields

Modifier and Type	Field	Description
static Object	SCORES	Alignment label for the likelyhood at each step.
static Object	SEQUENCE	Alignment label for the emitted sequence.
static Object	STATES	Alignment label for the state path.

Fields inherited from interface org.biojava.bio.alignment.Alignment

CONTENT

Fields inherited from interface org.biojava.bio.symbol.SymbolList

EDIT, EMPTY_LIST

Method Summary

Modifier and Type	Method	Description
double	getScore()	Return the overall score for this state-path and it's emissions.

Methods inherited from interface org.biojava.bio.alignment.Alignment

getLabels, subAlignment, symbolAt, symbolListForLabel, symbolListIterator

Methods inherited from interface org.biojava.utils.Changeable

addChangeListener, addChangeListener, isUnchanging, removeChangeListener, removeChangeListener

Methods inherited from interface org.biojava.bio.symbol.SymbolList

edit, getAlphabet, iterator, length, seqString, subList, subStr, symbolAt, toList

Field Detail

SEQUENCE

static final Object SEQUENCE

Alignment label for the emitted sequence.

STATES

static final Object STATES

Alignment label for the state path.

SCORES

static final Object SCORES

Alignment label for the likelyhood at each step.

Method Detail

getScore

double getScore()

Return the overall score for this state-path and it's emissions.

Returns:

the score